IMGT Web resources: IMGT repertoire

Alignment of alleles: Atlantic cod (Gadus morhua) IGHV4S1

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Germline genomic sequences are needed to confirm if the nucleotide substitutions result from somatic mutations or correspond to allelic polymorphisms.

                                  1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16  17  18  19  20
                                 A   Q   T   I   T   Q   S   E   P       V   V   A   E   L   M   E   S   H   T
  AJ274711,IGHV4S1*01, 11-39    GCT CAG ACA ATA ACA CAA TCT GAA CCA ... GTT GTT GCA GAG CTG ATG GAA TCA CAT ACA
                                                                                     K  
  AJ274712,IGHV4S1*02, 12-02a   --- --- --- --- --- --- --- --- --- ... --- --- --- A-- --- --- --- --- --- ---
                                                                                     K  
  AJ274713,IGHV4S1*03, 12-09    --- --- --- --- --- --- --- --- --- ... --- --- --- A-- --- --- --- --- --- ---

                                                        ___________________CDR1-IMGT____________________
                                 21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40
                                 L   T   C   T   Y   S   G   L   P   T   S   S   A                       F   A
  AJ274711,IGHV4S1*01, 11-39    TTG ACA TGC ACA TAT TCT GGA CTA CCA ACT AGT AGT GCA ... ... ... ... ... TTT GCC

  AJ274712,IGHV4S1*02, 12-02a   --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... --- ---

  AJ274713,IGHV4S1*03, 12-09    --- --- --- --- --- --- --- --- --- --- --C --- --- ... ... ... ... ... --- ---

                                                                                            _______________CDR2-
                                 41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                                 W   I   R   Q   N   E   E   K   G   L   E   W   I   A   Y   I   T   G   P   S
  AJ274711,IGHV4S1*01, 11-39    TGG ATC AGG CAG AAC GAA GAG AAG GGA CTG GAA TGG ATT GCA TAT ATA ACA GGA CCT AGT

  AJ274712,IGHV4S1*02, 12-02a   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

  AJ274713,IGHV4S1*03, 12-09    --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                IMGT________________
                                 61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76  77  78  79  80
                                 G   G   T   K       S   Y   S   V   S   V   K       G   R   F   T   I   S   R
  AJ274711,IGHV4S1*01, 11-39    GGG GGC ACC AAG ... TCC TAC TCT GTG TCG GTC AAG ... GGC CGC TTC ACC ATC TCA AGG

  AJ274712,IGHV4S1*02, 12-02a   --- --- --- --- ... --- --- --- --- --- --- --- ... --- --- --- --- --- --- ---

  AJ274713,IGHV4S1*03, 12-09    --- --- --- --- ... --- --- --- --- --- --- --- ... --- --- --- --- --- --- ---

                                 81  82  83  84  85  86  87  88  89  90  91  92  93  94  95  96  97  98  99 100
                                 D   N   D   N   Q   Q   V   H   L   Q   M   D   Q   L   E   T   A   D   S   A
  AJ274711,IGHV4S1*01, 11-39    GAC AAT GAC AAC CAG CAA GTA CAT CTC CAG ATG GAC CAG CTG GAG ACT GCG GAC TCC GCT

  AJ274712,IGHV4S1*02, 12-02a   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

  AJ274713,IGHV4S1*03, 12-09    --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                CDR3-IMGT
                                101 102 103 104 105 106 
                                 V   Y   Y   C   A   R
  AJ274711,IGHV4S1*01, 11-39    GTC TAT TAT TGT GCT AGA     #c

  AJ274712,IGHV4S1*02, 12-02a   --- --- --- --- --- ---     #c

  AJ274713,IGHV4S1*03, 12-09    --- --- --- --- --- ---     #c

#c: rearranged cDNA

This alignment of allele is automatically generated by Mehdi Yousfi alignment of allele tool.

Created: 21/01/2002
Author: Nathalie Bosc